Publications/ Patents


Publications:

  • Chen J, Haller CA, Jernigan FE, Koerner SK, Wong DJ, Wang Y, Cheong JE, Kosaraju R, Kwan J, Park DD, Thomas B, Bhasin S, De La Rosa RC, Premji AM, Liu L, Park E, Moss AC, Emili A, Bhasin M, Sun L, Chaikof EL.;" Modulation of Lymphocyte-Mediated Tissue Repair by Rational Design of Heterocyclic Aryl Hydrocarbon Receptor Agonists" Sci Adv. 2020 Jan 15;6

  • Tellechea A, Bai S, Dangwal S, Theocharidis G, Nagai M, Koerner S, Cheong JE, Bhasin S, Shih TY, Zheng Y, Zhao W, Zhang C, Li X, Kounas K, Panagiotidou S, Theoharides T, Mooney D, Bhasin M, Sun L, Veves A.; "Topical Application of a Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing", J Invest Dermatol. 2020 Apr;140(4):901-911

  • Philip A. Waghorn, Chloe M. Jones, Nicholas Rotile, Steffi Koerner, Diego D. S. Ferreira, Howard Chen, Clemens Probs, Andrew M. Tager, Peter Caravan; "Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine-Based Probe", Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9825-9828.

  • Steffi K. Koerner, Jun-ichi Hanai, Sha Bai, Finith E. Jernigan, Miwa Oki, Chieko Komaba, Emi Shuto, Vikas P. Sukhatme, Lijun Sun; “Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase”, Eur. J. Med. Chem. 2017, 126,  920-928.

  • Sha Bai, Masazumi Nagai, Steffi K. Koerner, Aristides Veves, Lijun Sun, “Structure-Activity Relationship Study and the Discovery of Indole and Indazole 3-Carboxamides as Calcium-Release Activated Calcium Channel”, Bioorg. Med. Chem. Lett. 2017, 27(3), 393-397.

  • Yiqiang Wang, Andreas Hedblom, Steffi K. Koerner, Mailin Li, Finith E. Jernigan, Barbara Wegiel, and     Lijun Sun, “Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation”, Bioorg. Med. Chem. Lett. 2016, 26 (23), 5703-5706.

  • Jean-Marc Lapierre, Sudharshan Eathiraj, David Vensel, Yanbin Liu, Cathy Bull, Susan Cornell-Kennon, Shin Iimura, Eugene Kelleher, Darin Kizer, Steffi Koerner, Sapna Makhija, Akihisa Matsuda, Magdi Moussa, Nivedita Namdev, Ronald Savage, Jeff Szwaya, Erika Volckova, Neil Westlund, Hui Wu, Brian Schwartz; “Discovery of 3-​(3-​(4-​(1-​Aminocyclobutyl)​phenyl)​-​5-​phenyl-​3H-​imidazo[4,​5-​b]​pyridin-​2-​yl)​pyridin-​2-​amine (ARQ 092)​: An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor", J. Med. Chem. 2016, 59(13), 6455-6469.

  • Mark A. Ashwell, Christopher Brassard, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Anton Filikov, Jason Hill, Steffi Koerner, Eoin Kelleher, Darin Kizer, Jean-Marc Lapierre, Yanbin Liu, Jeff Link, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Robert Nicewonger, Uma Uppalapati, Rocio Palma, Jeff Szwaya, Manish Tandon, David Vensel, Laurie Volak, Erika Volckova, Neil Westland, Hui Wu, Rui-Yang Yang; “Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines; Orally Bioavailable, Selective and Potent ATP-independent Akt Inhibitors”, J. Med. Chem. 2012, 55(11), 5291-5310.

  • Peter Caravan, Biplap Das, Qing Deng, Stephane Dumas, Vincent Jacques, Steffi Koerner, Andrew Kolodziej, Richard Looby, Zhaoda Zhang; “A lysine walk to high relaxivity collagen-targeted MRI contrast agents” Chem. Comm. 2009, 4, 430-432.

  • Kirsten Overoye-Chen, Steffi Koerner, Richard J. Looby, Andrew F. Kolodziej, Stephan G. Zech, Jaclyn M. Chasse, Thomas J. McMurry, Peter Caravan, “ EP-2104-R: a fibrin-specific gadolinium-based MRI contrast agent for the detection of thrombus”, J. Am. Chem Soc. 2007, 130(18), 6025-6039.

  • Peter Caravan, Biplab Das, Stephane Dumas, Frederick H Epstein, Patrick A.Helm, Vincent Jacques, Steffi Koerner, Andrew Kolodziej, Luhua Shen, Wei-Chuan Sun, Zhaoda Zhang; “Collagen-targeted MRI contrast agent for molecular imaging of fibrosis”, Angewandte Chemie, Int. Ed., 2007, 46(43), 8171-8173.

  • Jian Chen, Steffi K. Koerner, Stephen L. Craig, Shirley Lin, Dmitry M. Rudkevich and Julius Rebek, Jr., “Chemical amplification with encapsulated reagents”, PNAS, 2002, 99 (5), 2593-2596.

  • Jian Chen, Steffi Koerner, Stephen L. Craig, Dmitry M. Rudkevich, and Julius Rebek, Jr.; “Chemical amplification from compartmentalized reagents”, Nature, 2002, 415, 385-386.

  • Shivanyuk, K. Rissanen, S. Koerner, D. M. Rudkevich, J. Rebek, Jr., “Structural studies of  self-folding cavitands”, Helv Chem. Acta. 2000, 83, 1778-1789.

  • Steffi Koerner, Fabio C. Tucci, Dmitry M. Rudkevich, Thomas Heinz, Julius Rebek, Jr. “A self-assembled cylindrical capsule: new supramolecular phenomena through encapsulation”, Chem. Eur. J., 2000, 6, 187-195.

  • Steffi Koerner, Amanda Bryant-Friedrich, Bernd Giese, ”C-3’-branched thymidines as precursors for selective generation of C-3’-nucleoside-radicals”, J. Org. Chem., 1999, 64, 1559-1564.

  • Andreas Marx, Peter Erdmann, Martin Senn, Steffi Koerner, Tobias Jungo, Mario Petretta, Petra Imwinkelried, Adrian Dussy, Klaus Kulicke, Ludwig Macko, Margaretha Zehnder and Bernd Giese “Synthesis of 4’-C-acylated thymidines”, Helv. Chim. Acta, 1996, 79, 1980-1994.

  • Ingmar Bauer, Steffi Koerner, Beate Pawelke, Sahar Al-Malaika, Wolf D. Habicher “Hydroperoxide decomposing ability and hydrolytic stability of organic phosphites containing hindered amine moieties (HALS-Phosphites)”, Polym. Degr. Stab., 1998, 62, 175-186.

  • Ingmar Bauer, Wolf D. Habicher, Steffi Koerner, Sahar Al-Malaika “Antioxidant interaction between organic phosphites and hindered amine light stabilizers: effects during photo-oxidation of polypropylene”, Polym. Degr. Stab., 1997, 55, 217-224.

Patents:

  • Ashwell, Mark A.; Brassard, Chris; Filikov, Anton; Hill, Jason;Koerner, Steffi; Lapierre, Jean-Marc; Liu, Yanbin; Namdev, Nivedita; Nicewonger, Robert; Palma, Rocio; Tandon, Manish; Vensel, David; Matsuda, Akihisa; Imura, Shin; Yamamoto, Yuko; Isoyama, Takeshi:” Preparation of imidazopyridinylaminopyridine derivatives for use as antiproliferation agents” , WO 2012177844, A2.

  • Ashwell, Mark A.; Brassard, Chris; Filikov, Anton; Hill, Jason;Koerner, Steffi; Lapierre, Jean-Marc; Liu, Yanbin; Namdev, Nivedita; Nicewonger, Robert; Palma, Rocio; Tandon, Manish; Vensel, David; Matsuda, Akihisa; Imura, Shin; Yamamoto, Yuko; Isoyama, Takeshi:”Preparation of imidazopyridinyl derivatives for use as antiproliferation agents” WO 2012177852 A1, 2012.

  • Caravan, Peter D.; Kolodziej, Andrew; Zhang Zhaoda; Dumas, Stephane; Das, Biplab K.; Jacques, Vincent; Looby, Richard; Koerner, Steffi; Sun, Wei-Chuan; Buckler, David; Abujoub, Aida; Sato, Aaron K.:”Methods for Collagen Imaging” U.S. Pat. Appl. Publ. 2012, US20120114557.

  • Ashwell, Mark A.; Eathiraj, Sudharshan; Filikov, Anton; Koerner, Steffi; Lapierre, Jean-Marc; Liu, Yanbin; Palma, Rocio; Vensel, David; Iimura, Shin; Shiina, Akiko; Yoshida, Kenichi; Yamazaki, Takanori; Matsuda, Akihisa: “Substituted benzo-imidazo-pyrido-diazepine compounds”  U.S. Pat. Appl. Publ. 2012, US 20120108574 A1 20120503.

  • Ali, Syed M.; Ashwell, Mark A.; Kelleher, Eugene; Koerner, Steffi; Lapierre, Jean-Marc; Link, Jeffrey S.; Liu, Yanbin; Moussa, Magdi; Palma, Rocio; Tandon, Manish; Vensel, David; Westlund, Neil; Wu, Hui; Yang, Rui-Yang: “Preparation of substituted benzo-pyrido-triazolo-diazepine compounds as AKT kinase modulators useful for treating cell proliferative disorders”. WO 2011123678, 2011.

  • Ashwell, Mark A.; Brassard, Chris; Filikov, Anton; Hill, Jason; Koerner, Steffi; Lapierre, Jean-Marc; Liu, Yanbin; Namdev, Nivedita; Nicewonger, Robert; Palma, Rocio; Tandon, Manish; Vensel, David; Matsuda, Akihisa; Iimura, Shin; Yamamoto, Yuko: “Preparation of substituted imidazopyridinyl-aminopyridine compounds as antitumor agents”  WO 2011082270, 2011.

  • Ben-Zeev, Efrat; Chen, Dongli; Fichman, Merav; Ghosh, Shomir; Koerner, Steffi; Lin, Jian; Marantz, Yael; Melendez, Rosa; Mohanty, Pradyumna; Shacham, Sharon; Zhang, Zhaoda: “Preparation of carboxamide compounds and their use as antagonists of the chemokine CCR2 receptor”, PCT Int. Appl. (2009), WO 2009076404, 2009.

  • Ben-Zeev, Efrat; Chen, Dongli; Fichman, Merav; Ghosh, Shomir; Koerner, Steffi; Lin, Jian; Marantz, Yael; Melendez, Rosa; Mohanty, Pradyumna; Shacham, Sharon; Zhang, Zhaoda: “Preparation of substituted heterocyclylcarboxamide derivatives for use as chemokine receptor agonists” WO 2009076512, 2009.

  • Jian Lin, Dongli Chen, Steffi Koerner; Rosa Melendez, Pradyumna Mohanty, Efrat Ben-Zeev, Merav Fichman, Yael Marantz, Oren Becker, Dilara Mccauley, Pini Orbach, Ashis Saha, Sharon Shacham, Michael Xie, “Preparation of piperidinyl and pyrrolidinyl carboxamide compounds as chemokine receptor antagonists for treating diseases associated with monocyte, leukocyte and lymphocyte accumulation” WO 2008045564, 2008.

  • Peter D. Caravan; Andrew Kolodziej, Zhaoda Zhang, Stephane Dumas, Biplab K. Das, Vincent Jacques, Richard Looby, Steffi K. Koerner, Wei-Chuan Sun, David R. Buckler, Aida Abujoub, Aaron K. Sato, “Methods for myocardial imaging”, WO 2007084264,  2007. 

  • Zhaoda Zhang, Peter D. Caravan, Thomas, J. McMurry, Andrew Kolodziej, Shrikumar A. Nair, John C. Amedio, Stephane Dumas, Xifang Wang, Wei-Chuan Sun, Alexander L. Nivorozhkin, Steffi K. Koerner, “Peptide based multimeric targeted contrast agents”, WO 03/011115, 2003.

Presentations:

  • Talk: A. Tellechea, D. Eschuk, Y. Zheng, M. Nagai, S. Bai, S. Koerner, T. Shih, S. Panagiotidou, L. Pradhan-Nabzdyk, L. Sun, D. Mooney, T. Theoharides, A. Veves; “A noval therapeutic strategy for diabetic wounds: dressings delivering mast stabilizers”, Abstracts of Papers, WHS20160041, 2016.

  • Poster: N. D. Namdev · S. Cornell-Kennon · Y. Yu · J. Hill, C. Bull, L. Volak, J. Wang, D. Lowe, X. Gu, S. Koerner, M. Moussa,  D. Vensel, Y. Liu, H. Wu, C.-R. Chen, D. T. Dransfield, M. A. Ashwell, “Discovery and preliminary characterization of novel tyrosine kinase inhibitors with selectivity to BTK”, Abstract B270, Molecular Cancer Therapeutics 12(11Supplement), 2014.

  • Poster: Mark A. Ashwell, Christopher Brassard, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Anton Filikov, Jason Hill, Steffi Koerner, Eoin Kelleher, Darin Kizer, Jean-Marc Lapierre, Yanbin Liu, Jeff Link, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Robert Nicewonger, Uma Uppalapati, Rocio Palma, Jeff Szwaya, Manish Tandon, David Vensel, Laurie Volak, Erika Volckova, Neil Westland, Hui Wu, Rui-Yang Yang; “Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines; Orally Bioavailable, Selective and Potent ATP-independent Akt Inhibitors”, Abstracts of Papers, #LB-1, AACR 2012.

  • Poster: Jian Lin, Rosa Melendez, Pradyumna Mohanty, Steffi Koerner, Merav Fichman, Efrat Ben-Zeev, Dilara McCauley, Andrew Kolodziej, Christine Kitsos, Vincent Jacques, Qing Deng, Dongli Chen, Biplab Das, Sharon Shacham, Simon Jones, Yael Marantz, “Discovery of piperidine-4-carboxamides as potent chemokine receptor CCR2b antagonists, Part I: Structure-based design and structure-activity relationship studies”, Abstracts of Papers, 237th ACS Meeting, 2009.

  • Poster: Pradyumna Mohanty, Steffi Koerner, Rosa Melendez, Jian Lin, Dongli Chen, Merav Fichman, Efrat Ben-Zeev, Dilara McCauley, Andrew Kolodziej, Christine Kitsos, Vincent Jacques, Qing Deng, Biplab Das, Sharon Shacham, Simon Jones, Shomir Ghosh, Sheila Dewitt, “Discovery of piperidine-4-carboxamides as potent chemokine receptor CCR2b antagonists, Part II: Reduction of hERG ion channel affinity and CYP450 liability”, Abstracts of Papers, 237th ACS Meeting 2009.

  • Poster: Steffi Koerner, Andrew Kolodziej, Shrikumar Nair, Thomas McMurry, Alexander Nivoroshkin, Curtis Pratt, Wei-Chuan Sun, Xifang Wang, Zhaoda Zhang, Peter Caravan, Andrew Uprichard, “Optimization of fibrin-binding peptides as targeting vectors for thrombus specific MRI-contrast agents”, 236th ACS-meeting 2008.

  • Talk: Stephane Dumas, Steffi Koerner, Wei-Chuan Sun, Zhaoda Zhang, Elmar Spuentrup, Peter Caravan, “Collagen targeted Gd-Based MRI contast agent for steady state myocardial perfusion imaging” 236th ACS-meeting 2008.

  • Talk: Andrea J. Wiethoff, , Jufeng Wang, Ed C. Parsons, Jr., Hans Bauer, Claudia Heyer, Richard Looby, Kirsten Overoye-Chan, Steffi Koerner, Matt T. Greenfield, Qing Deng, Steve Witowski, Robert M. Weisskoff and Phil B. Graham. “In vivo detection of carotid artery thrombi by MRI and EP-2104R, a fibrin targeted imaging agent.” International Stroke Conference, New Orleans, LA, 2005.

  • Talk (invited): Steffi Koerner “High Relaxivity Contrast Reagents for MRI”, New Mexico State University, Las Cruces, Oct. 22, 2004.

  • Talk: Steffi Koerner, Stephen Craig, Dmitry Rudkevich, Julius Rebek, Jr “Supramolecular Control of Chemical Reactivity”, 219. ACS-Meeting, San Francisco, CA, USA, March 26, 2000.

  • Poster: “Selective Generation of C-3’-Deoxynucleoside Radicals”, Gordon Research Conference on Free Radicals, Holderness School, Plymouth, NH, USA, July 13-18, 1997.

  • Talk: ”Model Investigations in Radical Induced DNA-Cleavage via C-3’-Radicals” Forschungskolloquium des Verbandes der Chemischen Industrie, Stuttgart, Germany, 1996.

 

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